- autologous transplant - $ 50,000
- allogeneic transplantation (from a related donor) - $ 86,000
- allogeneic transplant (from an unrelated donor) - $ 120,000.
Why do patients choose Medical Park?
Medical Park Hospitals Group is the largest in Turkey. More than 600 bone marrow surgeries are conducted here annualy. The Clinic collaborates with international Bone Marrow Donor Banks. Medical Park is accredited by the European Committee on Organ Transplantation.
Doctors in the Clinic provide treatment for adults and children with blood cancers or disorders: leukemia, lymphoma, various types of anemia (aplastic anemia, Fanconi anaemia, thalassemias) and other.
Who performs the treatment?
Pediatric bone marrow transplant procedure is provided by the best Medical Park onco-hematologists - Prof. Akif Yeşilipek (30 years of experience) and Prof. Tunç Fişgin (21 years of experience).
- What is specialty in Anadolu Hospital?
- Who provides a bone marrow transplant?
- What is the bone marrow transplant cost at Anadolu?
What is specialty in Anadolu Hospital?
The Center of Stem Cell Transplantation at the Anadolu Medical Center belongs to TOP 5 medical institutions in Europe. The Center receives only patients older than 18 years for autologous (own cells) transplant and allogeneic (donor cells) BMT, as a stem cell transplant in children is not conducted in Anadolu Hospital. During the last 5 years Anadolu doctors have carried more than 1,000 surgeries (200 - to foreign patients).
The Transplant Department is based on two floors and equipped with 22 single wards and 16 wards of the Hematology Department. The risk of infection is brought to nought due to the high-efficiency particulate (HEPA) air-filters established in the patients wards, nursing rooms and corridors.
Who provides a bone marrow transplant?
A bone marrow transplant at the Anadolu Medical Center is provided by the Head of the Department, an international expert Prof. Zafer Gülbaş. Professor studied and worked in Turkey, Israel, the USA and Canada. Prof. Gülbaş has more than 30 years of experience in hematology practice, making him the most authoritative hematology specialist in the country.
What is the bone marrow transplant cost at Anadolu?
The cost of autologous (own bone marrow) transplant - $ 55,000.
The cost of allogeneic bone marrow transplant:
- from a related donor - $ 95,000;
- from an unrelated donor - $ 170,000.
- Why do patients choose Medipol Mega University Hospital?
- How much does a bone marrow transplant procedure cost?
- Bone marrow specialists in the Clinic
Why do patients choose Medipol Mega University Hospital?
The Medipol Mega University Hospital is among top Turkish hospitals with international accreditation of JCI. Bone marrow transplant procedure for adults and children are provided at the Center for Bone Marrow Transplant at Medipol. The bone marrow transplant success rate in Medipol Hospital is 92.5%. The amount of pediatric BM transplant in 2016 is about 100.
Bone marrow specialists in the Clinic
Stem cell transplant is performed by Assistant Prof. Sema Aktaş and Assistant Prof. Ebru Erbayat Altay - the most authoritative pediatric hematologists in Turkey. BMT for adults is carried out by Professor with 35 years of experience MD Deniz Sargin. She has performed hundreds of successful transplants of stem cells and bone marrow.
How much does a bone marrow transplant procedure cost?
- Autologous bone marrow transplant - $ 50,000.
- Allogeneic bone marrow transplant from a related donor - $ 75,000.
- Allogeneic bone marrow transplantation from an unrelated donor - $ 135,000.
Bone marrow transplant in Turkey
Bone marrow transplantation is a medical procedure to treat a number of diseases. It is aimed at restoring the patient's normal blood formation. The first operation of this kind was performed in 1968 and since that time the need for it has been constantly increasing. Every year more than a million transplants are carried out in the world.
Only in Turkey
The cost of the transplant is 50% less than in Europe.
Diseases treatable with BM transplant
Bone marrow transplantation is prescribed for the following diseases:
- Plasma cell myeloma;
- Breast cancer;
- Ovarian сancer.
- Immune system disorders:
- Multiple sclerosis;
- Lupus erythematosus;
- Blood disorders:
- Aplastic anemia;
- Sickle cell anemia.
- Metabolic diseases.
Indications and contraindications for bone marrow transplant
Indication for transplantation of bone marrow is achieving a condition in which own blood-forming tissue can not cope with its function. In non-cancer diseases it is the lack of production of stem cells, in leukosis it is their production in “immature” state.
Contraindications to the surgery are:
- Acute infectious diseases (hepatitis B and the C, syphilis, HIV).
- Diseases of the immune system.
- Severe diseases of internal organs.
- Elderly age.
- Long-term taking of hormonal drugs or antibiotics.
Types of bone marrow transplantation in Turkey
Transplant surgeries are divided according to the source of producing hematopoietic material for transplantation into:
- Autologous (transplantation of own hematopoietic cells, taken earlier).
- Homogeneous (material is transplanted from another person):
- related – of a close relative. A particular case of this type of transplant is syngenesiotransplantation, where the material of the twin is transplanted.
- unrelated –of an unrelated donor.
Autologous transplant is conducted to the patients with malignant tumors if the cancer has not affected bone marrow tissue or disease went into remission. It is important to conduct the transplantation before the tumor becomes resistant to treatment. This type of transplant does not create compatibility problems, which becomes the main when it is allogeneic.
Transplanted bone marrow must genetically match the tissues of the recipient. Otherwise there is a risk of complications of two types:
- Graft-versus-host when the transplanted cells perceive the recipient’s cells as “alien” and begin to attack them. The occurrence of such complication is extremely dangerous for the patient. In order to suppress the reaction, the drugs that suppress the immune system,immunosuppressants are assigned.
- Rejection reaction when the patient's immune system destroys the transplanted stem cells.
To prevent these reactions, the doctors of Turkish hospitals carefully select donor for allogeneic transplantation. The opportunity to use the close relatives - the patient’s brothers and sisters - as the donors are carefully checked. Pediatric patients have even higher chances as one of the parents can be a donor. If to pick up a related donor is not possible, specialists in Turkish hospitals choose unrelated donors in the Bone Marrow Donors Worldwide. In this case the genetic compatibility is more than 35%.
Diagnostics before transplant
In the clinics of Turkey, a patient and a donor have to undergo diagnostic procedures prior to the appointment of the surgery and the prevention of post-surgery complications. They include:
- Biochemical analysis of blood (including tests for glucose, creatinine, total protein and others);
- Bone marrow aspiration;
- Testing of lung function;
To identify the compatibility, the additional examinations are conducted:
- histocompatibility (HLA) and blood type;
- mixed leukocyte reaction;
- test for chimeric genes;
- pregnancy test (for female donors).
The Turkish clinics conduct the transplantation at six phases:
- Preparation. A preliminary course of chemotherapy and radiation therapy for cancer patients to kill cancer cells of hematopoietic tissue. The course lasts for 7-10 days.
- Collection. The needle is placed under the ilium or femoral bones, collecting the bone marrow. The amount of seized material is 2,000 ml. Collection is conducted under anaesthesia
- Processing. From the obtained composition specialists delaminate healthy stem cells, which are frozen at -80°C. To reduce the risk of rejection, T-lymphocytes are extracted from it. Processing lasts for 1-2 days.
- Transplantation. The obtained composition is inserted to the recipient by intravenous injection. The procedure is similar to a blood transfusion and lasts for two hours.
- Neutropenia. This means the phase of adaptation of the stem cells in the body. In the period of neutropenia leukocytes in blood are practically absent, so the immunity is significantly impaired. To prevent infection, the patient is placed in a special sterile box and prescribed to take antibacterial and antifungal drugs. The duration of neutropenia lasts for 2-4 weeks.
- Engraftment. If the surgery is successful, the patient's immune system is gradually recovering. To monitor the recovery process at this phase, the Turkish doctors carry out daily tests of the blood, gradually stopping the antibiotic treatment.
Rehabilitation after transplant
The rehabilitation process is associated primarily with the restoration of the patient's immune system. During this period it is necessary for the patient to limit communication and appearance in public places. (S)he should also carefully maintain good personal hygiene. Including the recommended usage of the protective bandage when leaving the house, ш recommend using a protective bandage. All the requirements are met in order to reduce the risk of infection. A year later, the patient takes vaccination against certain diseases.
During the period of rehabilitation attending doctors prescribe periodic examinations and analyzes to monitor the recovery of the body.
Recovery prognosis after bone marrow transplantation in Turkey
The survivability prognosis depends on the disease, the type of surgery, compatibility of the recipient and donor, and other factors. In Turkish hospitals it is on average 95% for adults and almost 100% for children.
Cost of the bone marrow transplant in Turkey
The cost for the surgery in Turkey is almost 50% lower than in the similar clinics in Europe and the USA. In addition, accommodation in the country at the time of treatment and the price of basic necessities are significantly lower than in European countries. It should also be noted that Turkey has a lot of affordable resorts recommended for rehabilitation.
Review of the patient after the bone marrow transplant in Turkey
“My child was hospitalized in the Turkish clinic with chronic leukemia. Unfortunately, the chemotherapy had not given the positive results, we needed a bone marrow transplant arose. Doctors recommended us to search for a donor among family members. We passed the tests and, fortunately, the sister appeared as an appropriate donor. Many thanks to the Turkish doctors, they literally were near my son all the time until he began to get better. It's been two years, and we still remember them fondly.”